Beauty Quickie: How soon should you apply moisturizer after cleansing your face or the rest of your skin? Aim to moisturize your skin as soon as possible, preferably within 60 seconds. After a minute dry air will literally begin to pull moisture from the skin. During winter, air tends to be even drier than other seasons which could only increase any dryness experienced. Keep skin smooth and supple by making a point to add moisture right after washing your face or showering.